Characterization of the pfmdr2 gene for Plasmodium falciparum. - Suppr | 超能文献

Characterization of the pfmdr2 gene for Plasmodium falciparum.

作者信息

Zalis M G, Wilson C M, Zhang Y, Wirth D F

出版信息

Mol Biochem Parasitol. 1994 Feb;63(2):311. doi: 10.1016/0166-6851(94)90068-x.

DOI:10.1016/0166-6851(94)90068-x

Abstract

摘要

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SC83288 is a clinical development candidate for the treatment of severe malaria.SC83288 是一种用于治疗重症疟疾的临床候选药物。

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The F423Y mutation in the pfmdr2 gene and mutations N51I, C59R, and S108N in the pfdhfr gene are independently associated with pyrimethamine resistance in Plasmodium falciparum isolates.疟原虫 Pfmdr2 基因中的 F423Y 突变和 pfdhfr 基因中的 N51I、C59R 和 S108N 突变均与疟原虫分离株中的嘧啶耐药性独立相关。

Antimicrob Agents Chemother. 2012 May;56(5):2750-2. doi: 10.1128/AAC.05618-11. Epub 2012 Feb 6.