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[马钱子种子生物碱化学成分的研究]

[Studies on the chemical constituents of alkaloids in seeds of Strychnos nux-vomica L].

作者信息

Yang X W, Yan Z K

机构信息

Jilin Academy of Traditional Chinese Medicine and Materia Medica, Changchun.

出版信息

Zhongguo Zhong Yao Za Zhi. 1993 Dec;18(12):739-40, 763-4.

PMID:7912074
Abstract

Thirteen alkaloids were isolated from the seeds of Strychnos nux-vomica. They were identified as strychnine, beta-colubrine, pseudostrychnine, strychnine N-oxide, brucime, brucine N-oxide, novacine, icajine, vomicine, isostrychnine, isobrucine, isobrucine N-oxide and isostrychnine N-oxide by chemical and spectroscopic analysis.

摘要

从马钱子种子中分离出13种生物碱。通过化学和光谱分析,它们被鉴定为士的宁、β-可鲁勃林、假士的宁、士的宁N-氧化物、布鲁西明、布鲁西明N-氧化物、新士的宁、伊卡精、催吐马钱子碱、异士的宁、异布鲁西明、异布鲁西明N-氧化物和异士的宁N-氧化物。

相似文献

1
[Studies on the chemical constituents of alkaloids in seeds of Strychnos nux-vomica L].[马钱子种子生物碱化学成分的研究]
Zhongguo Zhong Yao Za Zhi. 1993 Dec;18(12):739-40, 763-4.
2
The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism.马钱子种子生物碱对HepG2细胞的抗肿瘤作用及其可能机制
J Ethnopharmacol. 2006 Jun 30;106(2):179-86. doi: 10.1016/j.jep.2005.12.021. Epub 2006 Jan 26.
3
[Effect of processing on the alkaloids in Strychnos nux-vomica L].
Zhongguo Zhong Yao Za Zhi. 1994 May;19(5):277-9, 319.
4
[Pharmacokinetics of the alkaloids from the processed seeds of Strychnos nux-vomica in rats].[马钱子炮制后种子生物碱在大鼠体内的药代动力学]
Yao Xue Xue Bao. 2003 Jun;38(6):458-61.
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Cytotoxicities of alkaloids from processed and unprocessed seeds of Strychnos nux-vomica.马钱子炮制前后种子生物碱的细胞毒性
Zhongguo Yao Li Xue Bao. 1998 Sep;19(5):425-8.
6
[Influence of different processing methods of four alkaloid contents in Strychnos nux-vomica L].
Zhongguo Zhong Yao Za Zhi. 1995 Feb;20(2):84-6, 126.
7
The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway.马钱子种子中士的宁对人肝癌细胞的凋亡作用是通过涉及线粒体途径的Bcl-2和Ca2+介导的。
Toxicol Sci. 2006 May;91(1):59-69. doi: 10.1093/toxsci/kfj114. Epub 2006 Jan 27.
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[Effect of processing on the extraction of alkaloids from Strychnos].
Zhongguo Zhong Yao Za Zhi. 1993 Jan;18(1):23-4, 62.
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[Determination of alkaloids and comparison of the acute toxicity of differently processed products of the seeds of Strychnos nux-vomica L].
Zhongguo Zhong Yao Za Zhi. 1994 Oct;19(10):598-600, 638.
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The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells.马钱子种子中士的宁诱导的细胞毒性通过凋亡进行,并由SMMC 7221细胞中的环氧合酶2和半胱天冬酶3介导。
Food Chem Toxicol. 2007 Sep;45(9):1700-8. doi: 10.1016/j.fct.2007.03.004. Epub 2007 Mar 14.

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