敏感和难治性恶性肿瘤患者化疗后自体造血干细胞采集：一项多中心回顾性研究

Autologous blood stem cell collection after chemotherapy in patients with sensitive and refractory malignancies: a multicenter retrospective study.

作者信息

Pierelli L, Iacone A, Quaglietta A M, Nicolucci A, Menichella G, Benedetti Panici P, De Laurenzi A, De Rosa L, Fioritoni G, Indovina A

机构信息

Department of Hematology, Sacro Cuore Catholic University, Roma, Italy.

出版信息

Int J Artif Organs. 1993 Dec;16 Suppl 5:19-24.

PMID:7912230

Abstract

A retrospective study was undertaken to assess the factors affecting the yield of peripheral blood stem cell (PBSC) collections after chemotherapy. Fifty-five patients with malignancies, observed in 4 Italian Institutions from January 1987 to June 1991 were eligible for evaluation. This series included 19 non-Hodgkin lymphoma, 11 multiple myeloma, 9 ovarian cancer, 7 Hodgkin disease, 7 acute non-lymphocytic leukemia, 1 acute lymphoblastic leukemia, 1 neuroblastoma. Five hundred and twenty two PBSC collections were performed on 55 patients after a median of 18 days after the start of chemotherapy. The yields of PBSC collections were related to the dose of cytoreductive chemotherapy exploited for PBSC mobilization and to the number of circulating white blood cells, colony forming unit granulocyte/macrophage (CFU-GM) and the percentage of monocytes at the time of collection. Forty-eight patients out of 55 transplanted (87%) had rapid, complete and sustained engraftment. Three patients (5%) died of transplant related complications.

摘要

开展了一项回顾性研究，以评估化疗后影响外周血干细胞（PBSC）采集量的因素。1987年1月至1991年6月期间在4家意大利机构观察的55例恶性肿瘤患者符合评估条件。该系列包括19例非霍奇金淋巴瘤、11例多发性骨髓瘤、9例卵巢癌、7例霍奇金病、7例急性非淋巴细胞白血病、1例急性淋巴细胞白血病、1例神经母细胞瘤。在化疗开始后中位18天，对55例患者进行了522次外周血干细胞采集。外周血干细胞采集量与用于外周血干细胞动员的细胞减灭化疗剂量、采集时循环白细胞数量、集落形成单位粒细胞/巨噬细胞（CFU-GM）以及单核细胞百分比有关。55例患者中有48例（87%）接受移植后迅速、完全且持续植入。3例患者（5%）死于移植相关并发症。