Chiang M T, Otomo M I, Ito H, Furukawa Y, Kimura S
Department of Applied Biochemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
Atherosclerosis. 1994 Mar;106(1):21-8. doi: 10.1016/0021-9150(94)90079-5.
To investigate the effect of dietary eicosapentaenoic acid (EPA) on plasma lipoprotein levels, lecithin:cholesterol acyltransferase (LCAT) activity and liver acetyl CoA carboxylase activity, highly concentrated EPA (78%) purified from sardine oil was fed to stroke-prone spontaneously hypertensive rats (SHRSP) for 30 days. Significantly (P < 0.05) lower systolic blood pressure and plasma total cholesterol were observed in rats fed an EPA diet. In addition, higher HDL cholesterol and lower VLDL cholesterol levels were found in rats fed the EPA diet as compared with rats fed the control diet. However, no significant change of plasma LDL cholesterol was observed in rats between the two dietary groups. EPA supplementation increased the activity of plasma LCAT in rats. In addition, rats fed an EPA diet had lower liver total lipids and adipose tissue weights. However, higher liver acetyl CoA carboxylase activity was observed in rats fed the EPA diet. Results from the present study suggest that dietary EPA might stimulate the plasma lipoprotein metabolism and also alter lipogenesis in the liver of SHRSP rats.
为研究膳食二十碳五烯酸（EPA）对血浆脂蛋白水平、卵磷脂胆固醇酰基转移酶（LCAT）活性及肝脏乙酰辅酶A羧化酶活性的影响，将从沙丁鱼油中纯化得到的高浓度EPA（78%）喂饲易卒中型自发性高血压大鼠（SHRSP）30天。喂饲EPA饮食的大鼠收缩压和血浆总胆固醇显著降低（P<0.05）。此外，与喂饲对照饮食的大鼠相比，喂饲EPA饮食的大鼠高密度脂蛋白胆固醇水平较高，极低密度脂蛋白胆固醇水平较低。然而，两个饮食组大鼠的血浆低密度脂蛋白胆固醇未观察到显著变化。补充EPA可增加大鼠血浆LCAT的活性。此外，喂饲EPA饮食的大鼠肝脏总脂质和脂肪组织重量较低。然而，喂饲EPA饮食的大鼠肝脏乙酰辅酶A羧化酶活性较高。本研究结果表明，膳食EPA可能刺激SHRSP大鼠血浆脂蛋白代谢，并改变其肝脏中的脂肪生成。
