The role of molecular genetics in screening for multiple endocrine neoplasia type 1.

The gene causing MEN 1 has been localized to chromosome 11, band 11q13, by tumor deletion mapping studies and by family linkage studies. Molecular genetic markers flanking the MEN 1 gene have been defined, and they are of use in identifying disease gene carriers in a family. These individuals, who are at a high risk of developing the tumors of MEN 1, should undergo regular biochemical screening to detect the early onset of the disease. This combined use of molecular genetic and biochemical screening will help to improve the management of patients with MEN 1.