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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Panagopoulos N T, Matsokis N A

Department of Biology, University of Patras, Greece.

Gen Pharmacol. 1994 Jan;25(1):131-7. doi: 10.1016/0306-3623(94)90022-1.

[3H]Dopamine and [3H]spiperone binding to cerebellar homogenates was characterized utilizing dopaminergic agonists, antagonists and non-dopaminergic drugs. 2. The [3H]DA binding to low affinity binding sites reveals a heterogeneous population consisting of dopaminergic as well as serotonergic and noradrenergic sites. However, the high affinity binding of [3H]DA reflects dopaminergic sites, although a small contribution of serotonergic and noradrenergic binding sites cannot be excluded. 3. [3H]Spiperone also labels a heterogeneous population of binding sites which, however, are mainly dopaminergic.

利用多巴胺能激动剂、拮抗剂和非多巴胺能药物对[3H]多巴胺和[3H]螺哌隆与小脑匀浆的结合进行了表征。2. [3H]多巴胺与低亲和力结合位点的结合显示出一个异质群体，包括多巴胺能、血清素能和去甲肾上腺素能位点。然而，[3H]多巴胺的高亲和力结合反映了多巴胺能位点，尽管不能排除血清素能和去甲肾上腺素能结合位点的少量贡献。3. [3H]螺哌隆也标记了一个异质的结合位点群体，然而，这些位点主要是多巴胺能的。

Panagopoulos N T, Matsokis N A

Department of Biology, University of Patras, Greece.

Gen Pharmacol. 1994 Jan;25(1):131-7. doi: 10.1016/0306-3623(94)90022-1.

[3H]Dopamine and [3H]spiperone binding to cerebellar homogenates was characterized utilizing dopaminergic agonists, antagonists and non-dopaminergic drugs. 2. The [3H]DA binding to low affinity binding sites reveals a heterogeneous population consisting of dopaminergic as well as serotonergic and noradrenergic sites. However, the high affinity binding of [3H]DA reflects dopaminergic sites, although a small contribution of serotonergic and noradrenergic binding sites cannot be excluded. 3. [3H]Spiperone also labels a heterogeneous population of binding sites which, however, are mainly dopaminergic.

利用多巴胺能激动剂、拮抗剂和非多巴胺能药物对[3H]多巴胺和[3H]螺哌隆与小脑匀浆的结合进行了表征。2. [3H]多巴胺与低亲和力结合位点的结合显示出一个异质群体，包括多巴胺能、血清素能和去甲肾上腺素能位点。然而，[3H]多巴胺的高亲和力结合反映了多巴胺能位点，尽管不能排除血清素能和去甲肾上腺素能结合位点的少量贡献。3. [3H]螺哌隆也标记了一个异质的结合位点群体，然而，这些位点主要是多巴胺能的。