Misfeldt B B, Jörgensen P B, Spotoft H, Ronde F
Br J Anaesth. 1976 Oct;48(10):963-8. doi: 10.1093/bja/48.10.963.
The effects of droperidol and fentanyl on the intracranial pressure (i.c.p.) and cerebral perfusion pressure (c.p.p.) were studied in eight anaesthetized normocapnic patients with intracranial space-occupying lesions. The infection of droperidol resulted in a small and not significant increase in i.c.p. from 24.0 to 27.2 mm Hg, while c.p.p. decreased from 75.9 mm Hg to 57.8 mm Hg, as a result of a decrease in systemic arterial pressure. The addition of fentanyl produced no change in i.c.p., but a further decrease in arterial pressure decreased c.p.p. from 60.4 mm Hg to 47.8 mm Hg. In four patients values of c.p.p. less than 40 mm Hg were obtained. C.p.p. was was increased by hyperventilation in all but one of these patients. It is concluded that droperidol and fentanyl should be used in patients with intracranial hypertension only if hypocapnia has been established and when the arterial pressure is normal or increased.
在8例患有颅内占位性病变的麻醉状态下的正常碳酸血症患者中，研究了氟哌利多和芬太尼对颅内压（i.c.p.）和脑灌注压（c.p.p.）的影响。氟哌利多的应用导致颅内压从24.0毫米汞柱小幅升高至27.2毫米汞柱，但不显著，而由于体循环动脉压降低，脑灌注压从75.9毫米汞柱降至57.8毫米汞柱。添加芬太尼后颅内压无变化，但动脉压进一步降低使脑灌注压从60.4毫米汞柱降至47.8毫米汞柱。在4例患者中获得了低于40毫米汞柱的脑灌注压值。除1例患者外，所有这些患者通过过度通气使脑灌注压升高。得出的结论是，仅当已建立低碳酸血症且动脉压正常或升高时，氟哌利多和芬太尼才可用于颅内高压患者。
