N-去甲基地西泮在失眠患者及接受去甲替林治疗患者中的药代动力学
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline.
作者信息
Tognoni G, Gomeni R, De Maio D, Alberti G G, Franciosi P, Scieghi G
出版信息
Br J Clin Pharmacol. 1975 Jun;2(3):227-32. doi: 10.1111/j.1365-2125.1975.tb01580.x.
Abstract
1 Hospitalized patients suffering from insomnia were treated with N-demethyldiazepam (30 mg p.o.) for 10 days, while continuing treatment with nortriptyline (75 or 100 mg daily). 2 Clinical evaluation performed by objective rating scales showed a positive therapeutic effect. No correlation was found however between drug plasma levels and clinical efficacy. A high inter-individual variability was observed. 3 In three cases the N-demethyldiazepam disappearance curve showed a biexponential decay, with a slow first component followed by a faster one. 4 Compared with diazepam the tested drug has a longer plasma apparent half-life and a lower relative clearance.
摘要
- 患有失眠症的住院患者接受了去甲二氮卓（口服30毫克）治疗10天，同时继续使用去甲替林（每日75或100毫克）治疗。2. 通过客观评分量表进行的临床评估显示出积极的治疗效果。然而，未发现药物血浆水平与临床疗效之间存在相关性。观察到个体间存在高度变异性。3. 在三例患者中，去甲二氮卓的消除曲线显示为双指数衰减，第一个成分缓慢，随后是较快的成分。4. 与地西泮相比，受试药物的血浆表观半衰期更长，相对清除率更低。
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