Asakura W, Matsumoto K, Ohta H, Watanabe H
Section of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Pharmacol Biochem Behav. 1994 May;48(1):43-6. doi: 10.1016/0091-3057(94)90495-2.
Effects of monoamine synthesis inhibitors and dopamine antagonists on rapid eye movement sleep (REMs) deprivation treatment-induced increase in swimming activity were examined. Mice were deprived of REMs for 48 h by a small pedestal method. Swimming activity in REMs-deprived mice was significantly higher than those in group-housed or socially isolated animals used as the control. dl-alpha-Methyl- p-tyrosine methyl ester HCl (250 mg/kg, IP) decreased the swimming activity in REMs-deprived mice, whereas neither disulfiram (400 mg/kg, SC), a noradrenaline synthesis inhibitor, nor dl-p-chlorophenylalanine methyl ester HCl (300 mg/kg, IP) changed it. (+)-SCH23390 HCl (30 and 100 micrograms/kg, IP), a selective dopamine D1 antagonist, did not affect the activity in REMs-deprived mice. (+/-)-Sulpiride (12.5 and 25 mg/kg, IP), a selective dopamine D2 antagonist, dose-dependently decreased swimming activity in REMs-deprived mice, while it did not significantly change the swimming activity in the control animals. These results suggest that REMs deprivation treatment-induced increase in swimming activity is mainly due to the functional changes in the dopaminergic system rather than the noradrenergic or serotonergic system, and that dopamine D2 but not D1 receptor mechanism is involved in the increase in swimming activity in REMs-deprived animals.
研究了单胺合成抑制剂和多巴胺拮抗剂对快速眼动睡眠（REMs）剥夺治疗诱导的游泳活动增加的影响。通过小平台法使小鼠快速眼动睡眠剥夺48小时。快速眼动睡眠剥夺小鼠的游泳活动显著高于作为对照的群居或社会隔离动物。dl-α-甲基-对酪氨酸甲酯盐酸盐（250mg/kg，腹腔注射）降低了快速眼动睡眠剥夺小鼠的游泳活动，而作为去甲肾上腺素合成抑制剂的双硫仑（400mg/kg，皮下注射）和dl-对氯苯丙氨酸甲酯盐酸盐（300mg/kg，腹腔注射）均未改变其游泳活动。选择性多巴胺D1拮抗剂（+）-SCH23390盐酸盐（30和100μg/kg，腹腔注射）对快速眼动睡眠剥夺小鼠的活动没有影响。选择性多巴胺D2拮抗剂（±）-舒必利（12.5和25mg/kg，腹腔注射）剂量依赖性地降低了快速眼动睡眠剥夺小鼠的游泳活动，而对对照动物的游泳活动没有显著影响。这些结果表明，快速眼动睡眠剥夺治疗诱导的游泳活动增加主要是由于多巴胺能系统的功能变化，而非去甲肾上腺素能或5-羟色胺能系统的功能变化，并且多巴胺D2而非D1受体机制参与了快速眼动睡眠剥夺动物游泳活动的增加。
