啮齿动物离体胃制备物中迷走神经刺激胃酸分泌的比较分析。
Comparative analysis of the vagal stimulation of gastric acid secretion in rodent isolated stomach preparations.
作者信息
Welsh N J, Shankley N P, Black J W
机构信息
Department of Analytical Pharmacology, King's College School of Medicine & Dentistry, Rayne Institute, London.
出版信息
Br J Pharmacol. 1994 May;112(1):93-6. doi: 10.1111/j.1476-5381.1994.tb13035.x.
Abstract
- Electrical field stimulation produced a tetrodotoxin-sensitive, frequency-dependent, release of acid from isolated, lumen-perfused, stomach preparations from mouse, immature rat and guinea-pig. 2. In the guinea-pig and mouse preparations, the frequency-dependent response was abolished by hexamethonium, acetylcholine (ACh) muscarinic (M) and histamine H2-receptor blockade, consistent with the hypothesis that the vagal ACh acts indirectly by stimulating the release of endogenous histamine. 3. In contrast, in the rat preparation the frequency-dependent response was partially refractory to all of these inhibitors. However, a combination of H2- and ACh M-receptor blockade did abolish the effect. 4. We conclude that vagal-stimulated acid secretion in the rat, unlike the other two species, behaves as though there is a direct innervation of the oxyntic cells by either cholinergic or noncholinergic neurones.
摘要
- 电场刺激可使来自小鼠、未成熟大鼠和豚鼠的离体、腔内灌注胃制备物产生对河豚毒素敏感、频率依赖性的酸释放。2. 在豚鼠和小鼠制备物中，六甲铵、乙酰胆碱（ACh）毒蕈碱（M）和组胺H2受体阻断可消除频率依赖性反应，这与迷走神经ACh通过刺激内源性组胺释放而间接起作用的假说一致。3. 相比之下，在大鼠制备物中，频率依赖性反应对所有这些抑制剂均有部分抗性。然而，H2和ACh M受体阻断的联合作用确实消除了该效应。4. 我们得出结论，与其他两个物种不同，大鼠中迷走神经刺激引起的酸分泌表现为好像存在胆碱能或非胆碱能神经元对壁细胞的直接神经支配。
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