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High affinity uptake of glutamate and aspartate in the developing rat retina.

作者信息

Salceda R, Vilchis M C

机构信息

Departamento de Neurociencias, Instituto de Fisiología Celular, UNAM, México DF, México.

出版信息

Curr Eye Res. 1994 Apr;13(4):297-302. doi: 10.3109/02713689408995791.

DOI:10.3109/02713689408995791
PMID:7913432
Abstract

Uptake for glutamate and aspartate in both retina and synaptosomes was found to be saturable, temperature sensitive, sodium dependent and reduced by metabolic inhibitors. The P1 and P2 synaptosomal fractions showed high affinity systems for glutamate (3 and 9 microM) and aspartate (6 and 3 microM) respectively. Early after birth, glutamate accumulation was much higher than that of aspartate. It showed a rapid increase reaching the adult values about day 15. Aspartate uptake progressively increases with age up to about day 30. Our findings suggest that glutamate and aspartate may be transmitters at specific cell populations in the rat retina.

摘要

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