Lamoree M H, Reinhoud N J, Tjaden U R, Niessen W M, van der Greef J
Division of Analytical Chemistry, Lieden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.
Biol Mass Spectrom. 1994 Jun;23(6):339-45. doi: 10.1002/bms.1200230607.
For the enhancement of sample loadability and concentration sensitivity in capillary zone electrophoresis/mass spectrometry (CZE/MS) on-line isotachophoresis/capillary zone electrophoresis (ITP/CZE) in a single capillary prior to mass spectrometric detection is described for clenbuterol and some analogues. Concentration detection limits were found to be in the nanogram per millilitre range. The applicability of ITP/CZE/MS as a trace analysis technique is demonstrated by the determination of some beta-agonists in calf urine.
本文描述了一种用于在质谱检测前，在单根毛细管中进行毛细管区带电泳/质谱联用（CZE/MS）在线等速电泳/毛细管区带电泳（ITP/CZE）的方法，以提高样品加载能力和浓度灵敏度，该方法适用于克伦特罗及其一些类似物。浓度检测限在纳克每毫升范围内。通过测定小牛尿液中的一些β-激动剂，证明了ITP/CZE/MS作为一种痕量分析技术的适用性。
