Calne D B
Department of Medicine, University of British Columbia, Vancouver, Canada.
Neurology. 1994 Jul;44(7 Suppl 6):S19-22.
The initial decision in the management of idiopathic parkinsonism is whether any pharmacotherapy is indicated. There is no conclusive evidence that treatment is helpful before symptoms start to affect the patient's life, although some neurologists believe that deprenyl, also known as selegiline, could be useful. Once functional deficits begin to interfere with the patient's work or social activities, treating symptoms becomes appropriate. Anticholinergics and amantadine can be used, but their limited benefit is often accompanied by unacceptable adverse effects. Dopaminomimetics are the most satisfactory medications, including levodopa and such artificial dopamine agonists as bromocriptine, pergolide, or lisuride.
特发性帕金森病管理的首要决策是是否需要进行药物治疗。虽然一些神经科医生认为丙炔苯丙胺（也称为司来吉兰）可能有用，但在症状开始影响患者生活之前，尚无确凿证据表明治疗是有益的。一旦功能缺陷开始干扰患者的工作或社交活动，治疗症状就变得合适。可以使用抗胆碱能药物和金刚烷胺，但它们有限的益处往往伴随着难以接受的不良反应。拟多巴胺药物是最令人满意的药物，包括左旋多巴以及溴隐亭、培高利特或利苏力特等人工合成多巴胺激动剂。
