小龙虾中一种与FMRF酰胺相关的神经肽对突触调制的温度依赖性

Temperature dependence of synaptic modulation by a FMRFamide-related neuropeptide in crayfish.

作者信息

Friedrich R W, Quigley P A, Srivastava M, Skerrett M, Mercier A J

机构信息

Department of Biological Sciences, Brock University, St. Catharines ON, Canada.

出版信息

Neurosci Lett. 1994 Mar 14;169(1-2):56-8. doi: 10.1016/0304-3940(94)90355-7.

DOI:10.1016/0304-3940(94)90355-7

PMID:7914017

Abstract

The present study examined the temperature dependence of synaptic transmission and peptidergic modulation of chemical synapses on the phasic abdominal extensor muscles of crayfish. Decreasing the temperature from 25 degrees C to 5 degrees C in saline, decreased the EPSP amplitude by 88% and increased the EPSP half-decay time four-fold. The putative neurohormone DRNFLRFamide (DF2) increased EPSP amplitudes, but was more effective at 7-9 degrees C than at 15-17 degrees C. DF2 might play a hormonal role in counteracting low transmitter release at low temperature.

摘要

本研究检测了小龙虾腹侧伸肌化学突触的突触传递对温度的依赖性以及肽能调制。在盐溶液中将温度从25℃降至5℃，降低了兴奋性突触后电位（EPSP）幅度的88%，并使EPSP半衰期延长了四倍。假定的神经激素DRNFLRFamide（DF2）增加了EPSP幅度，但在7-9℃时比在15-17℃时更有效。DF2可能在低温下抵消低递质释放方面发挥激素作用。