Rehse K, Schleifer K J, Lüdtke E, Böhme E
Institut für Pharmazie, Freien Universität Berlin, Germany.
Arch Pharm (Weinheim). 1994 Jun;327(6):359-64. doi: 10.1002/ardp.19943270603.
Nitrososydnone-5-imines and Thiazole-2-nitrosimines are susceptible to photolytic cleavage of the = N-NO bond. This can be achieved with a tungsten lamp. In water the corresponding syndnone imine salts are formed in 90% yield at 37 degrees C. Only at higher temp. (70 degrees C) ring opening is observed. In methanol about 25% of sydnones are obtained. On the other hand NO. and N2O were detected in the head space of the reaction vials when oxygen was excluded. The formation of N2O from nitrososydnone imine was increased up to elevenfold by glutathione while the amount of NO. was decreased. In the presence of light and thiols soluble guanylate cyclase (s-GC) was stimulated. The results suggest that the nitroxylate anion NO- plays an important role in the stimulation of s-GC.
亚硝基乙二肟-5-亚胺和噻唑-2-亚硝基亚胺易于发生=N-NO键的光解断裂。这可以通过钨灯实现。在水中，相应的乙二肟亚胺盐在37℃时以90%的产率形成。仅在较高温度（70℃）下观察到开环。在甲醇中可得到约25%的乙二肟。另一方面，当排除氧气时，在反应瓶的顶空中检测到了一氧化氮和一氧化二氮。谷胱甘肽使亚硝基乙二肟亚胺生成一氧化二氮的量增加了多达11倍，而一氧化氮的量则减少。在光和硫醇存在的情况下，可溶性鸟苷酸环化酶（s-GC）受到刺激。结果表明，硝酰阴离子NO-在刺激s-GC中起重要作用。
