α-和β-肾上腺素能拮抗剂对肾上腺素诱导的人血小板聚集及细胞内游离钙浓度的影响。
Effects of alpha- and beta-adrenergic antagonist on epinephrine-induced aggregation and intracellular free calcium concentration in human platelets.
作者信息
Kimura Y, Okuda H
机构信息
2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.
出版信息
Biochem Biophys Res Commun. 1994 Jul 29;202(2):1069-75. doi: 10.1006/bbrc.1994.2037.
Recently, it has been reported that an alpha-adrenergic antagonist phentolamine inhibits epinephrine-induced platelet aggregation but a beta-adrenergic antagonist propranolol did not. In this study, we examined the effects of alpha- and beta-adrenergic antagonist on cytosolic free calcium movements induced by epinephrine. An alpha-adrenergic antagonist phentolamine was found to inhibit the elevation of cytosolic free calcium concentration induced by epinephrine, while a beta-adrenergic antagonist propranolol had no effect on cytosolic free calcium concentration induced by epinephrine.
最近，有报道称α-肾上腺素能拮抗剂酚妥拉明可抑制肾上腺素诱导的血小板聚集，而β-肾上腺素能拮抗剂普萘洛尔则无此作用。在本研究中，我们检测了α-和β-肾上腺素能拮抗剂对肾上腺素诱导的胞质游离钙运动的影响。发现α-肾上腺素能拮抗剂酚妥拉明可抑制肾上腺素诱导的胞质游离钙浓度升高，而β-肾上腺素能拮抗剂普萘洛尔对肾上腺素诱导的胞质游离钙浓度无影响。
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