Lamb V L, Schwartz A J, Rohn W R, Kaiser L
Department of Physiology, Michigan State University, East Lansing 48824-1101.
Eur J Pharmacol. 1994 Apr 21;256(2):221-6. doi: 10.1016/0014-2999(94)90250-x.
Experiments were done on aortic rings (thoracic and abdominal) from young and retired breeder Lewis and Sprague-Dawley male rats. Constriction responses to norepinephrine, 5-hydroxytryptamine (5-HT), and prostaglandin F2 alpha, were done +/- the cyclooxygenase blockers, indomethacin or mefenamic acid. Indomethacin significantly depressed norepinephrine constriction in abdominal (but not thoracic) aorta of all groups. In additional studies of abdominal aorta from Lewis retired breeders, indomethacin and mefenamic acid depressed norepinephrine (but not 5-HT or prostaglandin F2 alpha) construction. Furthermore, indomethacin depressed norepinephrine constriction in vessels denuded of endothelial cells. The thromboxane receptor antagonist SQ 29548 did not alter norepinephrine constriction. Thus, in rat abdominal aorta, norepinephrine constriction is mediated by a constrictor prostanoid of vascular smooth muscle origin that is not thromboxane A2.
对年轻和老龄繁殖期的Lewis和Sprague-Dawley雄性大鼠的主动脉环（胸主动脉和腹主动脉）进行了实验。在使用或不使用环氧化酶阻滞剂吲哚美辛或甲芬那酸的情况下，检测了去甲肾上腺素、5-羟色胺（5-HT）和前列腺素F2α引起的收缩反应。吲哚美辛显著降低了所有组腹主动脉（而非胸主动脉）对去甲肾上腺素的收缩反应。在对Lewis老龄繁殖期大鼠腹主动脉的进一步研究中，吲哚美辛和甲芬那酸降低了去甲肾上腺素（而非5-HT或前列腺素F2α）引起的收缩。此外，吲哚美辛降低了去内皮细胞血管对去甲肾上腺素的收缩反应。血栓素受体拮抗剂SQ 29548并未改变去甲肾上腺素引起的收缩。因此，在大鼠腹主动脉中，去甲肾上腺素引起的收缩是由一种血管平滑肌来源的收缩性前列腺素介导的，而非血栓素A2。
