Murray T J
Can Med Assoc J. 1976 Nov 6;115(9):892-4.
In a double-blind crossover study 12 patients with essential tremor were treated with propranolol and a placebo; 8 improved with propranolol and 3 with the placebo; the degree of improvement with propranolol was greater. In a similar study with diazepam 5 of 12 improved with diazepam and 4 of 12 with the placebo; the degree of improvement was less than that achieved with propranolol. Response in 21 patients to treatment with propranolol for 2 to 4 years was excellent in 4, good in 4 and fair in 10; the condition of 1 was unchanged and that of 2, worse. Excellent response was maintained for as long as 4 years, but response tended to deteriorate with time if initially it was less than excellent. Response decreased with increasing age. No patient 60 years of age or older had an excellent response, and the four with an excellent response were under age 55, three being under age 35; all four had had their tremor less than 12 years. Patients with essential tremor should be given a 3-month trial of propranolol at 120 mg/d; if no significant response is seen the dose should be decreased, then the drug discontinued.
在一项双盲交叉研究中，12例特发性震颤患者接受了普萘洛尔和安慰剂治疗；8例使用普萘洛尔后病情改善，3例使用安慰剂后病情改善；使用普萘洛尔后的改善程度更大。在一项使用地西泮的类似研究中，12例中有5例使用地西泮后病情改善，12例中有4例使用安慰剂后病情改善；改善程度小于使用普萘洛尔所达到的程度。21例患者接受普萘洛尔治疗2至4年，4例效果极佳，4例良好，10例一般；1例病情未变，2例病情恶化。极佳的效果持续了长达4年，但如果最初效果不是极佳，随着时间推移效果往往会变差。效果随年龄增长而降低。60岁及以上的患者无一人效果极佳，4例效果极佳的患者年龄均在55岁以下，3例在35岁以下；这4例患者的震颤病史均少于12年。特发性震颤患者应给予普萘洛尔120毫克/天、为期3个月的试验性治疗；如果未见明显效果，应减少剂量，然后停药。
