致癌和促肿瘤的种子植物和蕨类植物及其活性成分。

Oncogenic and tumor-promoting Spermatophytes and Pteridophytes and their active principles.

作者信息

Farnsworth N R, Bingel A S, Fong H H, Saleh A A, Christenson G M, Saufferer S M

出版信息

Cancer Treat Rep. 1976 Aug;60(8):1171-214.

Abstract

A survey and discussion are presented of plants classified as Spermatophyta and Pteridophyta, extracts of which have been shown to be oncogenic or tumor-promoting in animals. The active oncogenic and tumor-promoting principles, where known, have been identified. They represent tannins; pyrrolizidine, indole, tropolone, quinoline, purine, and benzophenanthridine alkaloids; nitroso compounds; triterpene glycosides; lignans; isoflavans; allyl benzenoids; simple (nu-pyrenes; and carbocyclic hydroxy acids. A total of 28 compounds of known structure have been identified as oncogens and several phorbol esters as tumor-promoters. Plants known to contain any of the 28 oncogens (excluding shikimic acid and caffeine) have been tabulated; they represent at least 454 species, 110 genera, and 34 families of Spermatophyta and Pteridophyta.

摘要

本文对分类为种子植物门和蕨类植物门的植物进行了综述和讨论，这些植物的提取物已被证明在动物体内具有致癌或促癌作用。已知的活性致癌和促癌成分已被鉴定出来。它们包括单宁；吡咯里西啶、吲哚、托酚酮、喹啉、嘌呤和苯并菲啶生物碱；亚硝基化合物；三萜糖苷；木脂素；异黄酮；烯丙基苯类化合物；简单的（新吡喃）；以及碳环羟基酸。共有28种已知结构的化合物被鉴定为致癌物质，还有几种佛波酯被鉴定为促癌物质。已知含有这28种致癌物质（不包括莽草酸和咖啡因）的植物已被制成表格；它们至少代表种子植物门和蕨类植物门的454个物种、110个属和34个科。