人类磷脂酰肌醇转移蛋白（PITPN）编码基因定位于17p13.3：一个与果蝇视网膜变性B基因（rdgB）具有同源性的基因。
Localization of the gene encoding human phosphatidylinositol transfer protein (PITPN) to 17p13.3: a gene showing homology to the Drosophila retinal degeneration B gene (rdgB).
作者信息
Fitzgibbon J, Pilz A, Gayther S, Appukuttan B, Dulai K S, Delhanty J D, Helmkamp G M, Yarbrough L R, Hunt D M
机构信息
Department of Molecular Genetics, University of London, UK.
出版信息
Cytogenet Cell Genet. 1994;67(3):205-7. doi: 10.1159/000133823.
PMID:7914867
Abstract
The human gene for phosphatidylinositol transfer protein (PITPN) has previously been shown to share sequence and functional homology to part of the Drosophila retinal degeneration B gene (rdgB). In view of the possible involvement of the PITPN locus in the etiology of retinal disease, the gene has been mapped to human chromosome 17p13.3 and mouse Chromosome 11.
摘要
此前已证明，人类磷脂酰肌醇转移蛋白（PITPN）基因与果蝇视网膜变性B基因（rdgB）的部分序列和功能具有同源性。鉴于PITPN基因座可能参与视网膜疾病的病因，该基因已被定位到人类17号染色体p13.3区域和小鼠11号染色体。
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