Sorochinskiĭ B V, Prokhnevskiĭ A I, Grodzinskiĭ D M, Shmigovskaia V V
Tsitol Genet. 1994 Jan-Feb;28(1):3-9.
The features of antimitotic substances as radioprotectors were studied. In vitro experiments have demonstrated that taxol revealed radioprotective features concerning the process of polymerization of irradiated microtubules. These results were the basis for the use of taxol and some other substances with high affinity for cytoskeleton proteins as potential radiomodificators in vivo. Experiments with cultivated fibroblasts revealed that colchicine significantly enhances radioactive injuries of cells while taxol and phalloidin manifest their radioprotective features.
研究了抗有丝分裂物质作为辐射防护剂的特性。体外实验表明，紫杉醇在受辐射微管的聚合过程中显示出辐射防护特性。这些结果为将紫杉醇和其他一些对细胞骨架蛋白具有高亲和力的物质用作体内潜在的辐射修饰剂奠定了基础。对培养的成纤维细胞进行的实验表明，秋水仙碱会显著加重细胞的放射性损伤，而紫杉醇和鬼笔环肽则表现出它们的辐射防护特性。
