多药耐药基因1（MDR1）在骨髓增生异常综合征及由骨髓增生异常综合征演变而来的急性髓系白血病中的表达
MDR1 gene expression in myelodysplastic syndrome and in acute myeloid leukemia evolving from myelodysplastic syndrome.
作者信息
Zöchbauer S, Gsur A, Götzl M, Wallner J, Lechner K, Pirker R
机构信息
Clinic for Internal Medicine I, University of Vienna, Austria.
出版信息
Anticancer Res. 1994 May-Jun;14(3B):1293-5.
The expression of the MDR1 gene, a multidrug resistance gene, was determined in patients (N = 24) with myelodysplastic syndrome or acute myeloid leukemia evolving from it. MDR1 RNA expression of the mononuclear cells was detected in 14 (58%) patients. Among patients who had progressed to acute myeloid leukemia (sAML) (N = 14), MDR1 RNA expression was seen in 8 (57%) patients. Expression was observed in the 2 patients who had been pretreated with MDR drugs. These findings indicate that the MDR1 gene is frequently expressed in MDS or sAML and suggest that multidrug resistance might be involved in the clinical drug resistance of these diseases.
对24例骨髓增生异常综合征或由其演变而来的急性髓系白血病患者进行了多药耐药基因MDR1的表达检测。14例（58%）患者的单核细胞中检测到MDR1 RNA表达。在已进展为急性髓系白血病（sAML）的患者（n = 14）中，8例（57%）患者出现MDR1 RNA表达。在2例曾接受MDR药物预处理的患者中也观察到了表达。这些发现表明，MDR1基因在骨髓增生异常综合征或sAML中经常表达，提示多药耐药可能与这些疾病的临床耐药有关。
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