Portnoy O, Granot E, Katz S
Dept. of Pediatrics, Hadassah-University Hospital, Jerusalem.
Harefuah. 1994 Apr 15;126(8):443-7, 491.
The differential diagnosis between intrahepatic and extrahepatic cholestasis in the newborn is difficult and has therapeutic implications. 61 cases of neonatal cholestasis were retrospectively analyzed to assess the efficacy of various tests and procedures in differentiating between the 2 types. Determination of serum gamma-glutamyl transpeptidase, ultrasonography and radionuclide scanning differed significantly in the 2 types (p '0.05 for all 3 determinations). A diagnostic program for evaluation of infants with neonatal cholestasis is proposed.
新生儿肝内胆汁淤积和肝外胆汁淤积的鉴别诊断较为困难,且具有治疗意义。对61例新生儿胆汁淤积病例进行回顾性分析,以评估各种检查和程序在区分这两种类型中的有效性。血清γ-谷氨酰转肽酶测定、超声检查和放射性核素扫描在这两种类型中存在显著差异(所有3项测定的p均<0.05)。提出了一个用于评估新生儿胆汁淤积婴儿的诊断方案。