Lachowicz A, Pawlikowski M, Ochedalski T
Department of Experimental Endocrinology and Hormone Research, Medical University of Lódź, Poland.
Biochem Biophys Res Commun. 1994 Aug 30;203(1):379-84. doi: 10.1006/bbrc.1994.2193.
The effects of somatostatin-14 on inositol-1,4,5-trisphosphate (IP3) content were examined in rat pituitary, hippocampus and cortex homogenates. Somatostatin increased IP3 concentration in all these investigated regions in a dose- and time-dependent manner. Maximal increase of IP3 content was found in the pituitary homogenate, and in the hippocampal and cortex homogenates the IP3 argumentation was slightly smaller. Time-response studies showed that this effect declined with extended time of incubation. These results suggest that IP3 is involved in the mechanism of action of somatostatin in brain.
在大鼠垂体、海马和皮质匀浆中研究了生长抑素-14对肌醇-1,4,5-三磷酸（IP3）含量的影响。生长抑素以剂量和时间依赖性方式增加所有这些研究区域中的IP3浓度。在垂体匀浆中发现IP3含量的最大增加，而在海马和皮质匀浆中IP3的增加幅度略小。时间反应研究表明，随着孵育时间延长，这种作用减弱。这些结果提示IP3参与了生长抑素在脑中的作用机制。
