Boccardi G
Centro Ricerche Sanofi-Midy S.p.A, Milan, Italy.
Farmaco. 1994 Jun;49(6):431-5.
In the study of the degradation of drug substances by molecular oxygen, their specific reaction mechanisms must be taken into account. The rate-determining step is usually the reaction of the substrate with a radical chain initiator, which is often an unknown impurity. The reactivity and selectivity of autoxidation can be controlled better by using a radical chain initiator, such as AIBN, than by changing the temperature or the oxygen pressure. In this paper the products profiles of four pharmaceutical substances in a simple oxidation test with AIBN are compared with the results of long term natural stability tests or with already established stabilities.
在研究药物分子被分子氧降解时，必须考虑其具体的反应机制。速率决定步骤通常是底物与自由基链引发剂的反应，而该引发剂往往是未知杂质。与改变温度或氧气压力相比，使用自由基链引发剂（如偶氮二异丁腈）能更好地控制自氧化的反应活性和选择性。本文将四种药物在使用偶氮二异丁腈的简单氧化试验中的产物谱与长期自然稳定性试验结果或已确定的稳定性进行了比较。
