Morales M A, Alonso-de-Florida F
Departamento de Biología del Desarrollo, Instituto de Investigaciones Biomédicas, U.N.A.M., México, D.F.
Bol Estud Med Biol. 1993 Jan-Dec;41(1-4):8-12.
The known two-stage facilitation/depression pattern of postganglionic responses was found at high (24 Hz) frequency stimulation of the preganglionic nerves. We found that the depression stage was exaggerated under partial hexamethonium blockade but it was not affected by partial transection of the preganglionic trunk. At low frequency (8 Hz) normal recruitment turned into the familiar two-stage pattern under moderated hexamethonium doses. The depression course under the competitive nicotinic antagonist dihydro-beta-erythroidine was markedly slower than under hexamethonium. These observations are accountable to the known use-dependence effect of hexamethonium.
在对神经节前神经进行高频(24赫兹)刺激时,发现了已知的节后反应两阶段促进/抑制模式。我们发现,在部分六烃季铵阻断的情况下,抑制阶段被夸大,但神经节前干的部分横断对其没有影响。在低频(8赫兹)时,在适度剂量的六烃季铵作用下,正常的募集转变为熟悉的两阶段模式。竞争性烟碱拮抗剂二氢-β-刺桐碱作用下的抑制过程明显比六烃季铵作用下的慢。这些观察结果可归因于已知的六烃季铵的使用依赖性效应。