Morales M A, Alonso-deFlorida F
Bol Estud Med Biol. 1989 Jan-Jun;37(1-2):42-9.
The present investigation was aimed to answer the following elementary, though important question concerning the sympathetic ganglion: Do the decentralized preganglionic terminals retain their full capacity to develop posttetanic potentiation (PTP) before substantial Wallerian degeneration takes place? Experiments were performed on the cat superior cervical ganglion in situ, and they followed a factorial design. The factors were: tetanization (supramaximal pulses, 0.2 ms, 24 Hz, 30 s), acute decentralization, and moderate hexamethonium blockade (5 mg/kg). Two levels were dealt with, namely, the indicated maneuvers were either performed or not performed. PTP was was measured in the S2 wave and the following variables were studied: decay constant, area under the curve and delay to summit occurrence. The analysis of variance showed that decentralization did not affect the development of PTP. Therefore, the nondegenerated terminals are fully capable of sustaining PTP, without the aid of the preganglionic cell bodies.
在实质性沃勒变性发生之前，去传入的节前终末是否仍保留其产生强直后增强（PTP）的全部能力？实验在猫的原位颈上神经节上进行，采用析因设计。因素包括：强直刺激（超强脉冲，0.2毫秒，24赫兹，30秒）、急性去传入以及适度的六甲铵阻断（5毫克/千克）。研究了两个水平，即上述操作执行或不执行。在S2波中测量PTP，并研究以下变量：衰减常数、曲线下面积和达到峰值的延迟。方差分析表明，去传入不影响PTP的产生。因此，未变性的终末完全有能力在没有节前细胞体帮助的情况下维持PTP。
