Weaver D, Walker L, Alcorn D, Skinner S
Department of Physiology, University of Melbourne, Parkville, Australia.
Comp Biochem Physiol Comp Physiol. 1994 May;108(1):107-16. doi: 10.1016/0300-9629(94)90061-2.
Xeric-adaptation was studied during 28 days of total water deprivation (TWD) in Notomys alexis. Beyond 7 days, the initial reductions in body weight and increases in haematocrit, plasma renin and juxtaglomerular (JG) cell morphological activity returned to normal. Mus musculus showed similar changes at 7 days but could not be maintained thereafter. TWD decreased the blood pressure of Notomys but endogenous angiotensin and vasopressin did not support pressure to a greater extent than controls, as revealed by selective antagonists. The normal morphology of the JG apparatus in Notomys was similar to other rodents. Fluid volume and blood pressure maintenance during TWD in Notomys do not depend upon enhanced activities of the renin-angiotensin and antidiuretic hormonal systems.
在对荒漠小鼠进行28天完全禁水（TWD）期间，对其干旱适应情况进行了研究。7天之后，体重最初的减轻以及血细胞比容、血浆肾素和肾小球旁（JG）细胞形态学活性的增加恢复到了正常水平。小家鼠在7天时表现出类似变化，但此后无法维持。TWD降低了荒漠小鼠的血压，但选择性拮抗剂显示，内源性血管紧张素和血管加压素对血压的支持程度并不比对照组更大。荒漠小鼠JG装置的正常形态与其他啮齿动物相似。荒漠小鼠在TWD期间的液体量和血压维持并不依赖于肾素 - 血管紧张素和抗利尿激素系统活性的增强。
