血管紧张素II对血压正常孕妇子宫胎盘及脐循环的影响。
The effect of angiotensin II on utero-placental and umbilical circulation in normotensive pregnant women.
作者信息
Yunohara T, Ito M, Sakoda Y, Okamura H
机构信息
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Japan.
出版信息
Int J Gynaecol Obstet. 1994 May;45(2):117-23. doi: 10.1016/0020-7292(94)90118-x.
OBJECTIVES
The angiotensin sensitivity test (AST) has been used to identify pregnant women likely to develop pre-eclampsia. The purpose of this study was to evaluate uteroplacental circulation and fetal response to angiotensin II (A-II).
METHODS
We studied blood flow velocity waveforms in the uterine and umbilical arteries of 23 normotensive pregnant women before, during and after the AST by Doppler ultrasonography. Fetal well-being was documented with biophysical profiles (BPS). ANOVA and two-way analysis of variation were used to analyze the results.
RESULTS
Infusion of A-II to normotensive pregnant women did not affect umbilical artery resistance at 20 or 30 weeks' gestation. Uterine artery resistance and maternal heart rate decreased significantly at 20 weeks' gestation with an AST-induced 10 mmHg or 20 mmHg rise in diastolic blood pressure. The BPS were not altered after the AST.
CONCLUSIONS
The AST does not increase vascular resistance in the uterine or umbilical circulation, and may be considered a safe procedure for both the mother and fetus.
目的
血管紧张素敏感性试验（AST）已被用于识别可能发生子痫前期的孕妇。本研究的目的是评估子宫胎盘循环及胎儿对血管紧张素II（A-II）的反应。
方法
我们通过多普勒超声研究了23名血压正常的孕妇在AST之前、期间及之后子宫和脐动脉的血流速度波形。用生物物理评分（BPS）记录胎儿健康状况。采用方差分析和双向变异分析来分析结果。
结果
向血压正常的孕妇输注A-II在妊娠20周或30周时不影响脐动脉阻力。在妊娠20周时，AST导致舒张压升高10 mmHg或20 mmHg，子宫动脉阻力和母体心率显著降低。AST后BPS未改变。
结论
AST不会增加子宫或脐循环中的血管阻力，对于母亲和胎儿而言，可被视为一种安全的检查方法。
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