子宫乳头状浆液性腺癌。p53和c-erbB-2表达及DNA含量的10例研究。
Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content.
作者信息
Prat J, Oliva E, Lerma E, Vaquero M, Matías-Guiu X
机构信息
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain.
出版信息
Cancer. 1994 Sep 15;74(6):1778-83. doi: 10.1002/1097-0142(19940915)74:6<1778::aid-cncr2820740621>3.0.co;2-5.
BACKGROUND
Uterine papillary serous adenocarcinoma (UPSA) is a highly aggressive neoplasm with a great tendency for dissemination. p53 and c-erbB-2 immunoreactivity and DNA ploidy are considered to be indicators of prognosis for endometrial carcinomas.
METHODS
Ten cases of patients with UPSA are reported. An attempt to relate pathologic findings with immunohistochemical stains for p53- and c-erbB-2-associated proteins, ploidy, and survival was made.
RESULTS
Three patients were classified as having Stage I; three, Stage II; two, Stage III; and two, Stage IV. Myometrial invasion was present with nine tumors and involved over 50% of the myometrial thickness in five. Uterine lymph vessel invasion was detected in seven cases. Peritoneal spread occurred in six patients. Overexpression of p53 was observed in six tumors, immunoreactivity for c-erbB-2 in four, and aneuploidy in seven. However, only peritoneal spread correlated significantly with survival (P < 0.005).
CONCLUSIONS
UPSA is a tumor with a high metastatic potential that exhibits immunoreactivity for p53 and c-erbB-2 and aneuploidy more often than that reported for conventional endometrioid adenocarcinomas.
背景
子宫乳头状浆液性腺癌（UPSA）是一种具有高度侵袭性且极易发生播散的肿瘤。p53和c-erbB-2免疫反应性以及DNA倍体被认为是子宫内膜癌预后的指标。
方法
报告了10例UPSA患者。尝试将病理结果与p53和c-erbB-2相关蛋白的免疫组化染色、倍体情况及生存率相关联。
结果
3例患者为Ⅰ期；3例为Ⅱ期；2例为Ⅲ期；2例为Ⅳ期。9个肿瘤存在肌层浸润，其中5个肌层浸润超过肌层厚度的50%。7例检测到子宫淋巴管浸润。6例患者发生腹膜播散。6个肿瘤观察到p53过表达，4个有c-erbB-2免疫反应性，7个为非整倍体。然而，只有腹膜播散与生存率显著相关（P < 0.005）。
结论
UPSA是一种具有高转移潜能的肿瘤，与传统子宫内膜样腺癌相比，其p53和c-erbB-2免疫反应性及非整倍体更为常见。
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