Schneider J, Efferth T, Rodriguez-Escudero F J, Volm M
Gynecologic Oncology Service, Hospital de Cruces, Universidad del Pais Vasco, Bilbao, Spain.
Chemotherapy. 1994 Jul-Aug;40(4):265-71. doi: 10.1159/000239203.
Endometrial carcinoma is considered a tumor which does not respond well to chemotherapeutic treatment. Among the various mechanisms of resistance to chemotherapy which are under investigation, two of them (multidrug resistance, mediated by P-glycoprotein, and glutathione-S-transferase-pi [GST-pi] overexpression) are of great interest for gynecologic oncologists, because they involve several drugs commonly used in practice, among which Adriamycin and cisplatin are probably the most important ones. We have studied 23 human endometrial carcinomas of different histological varieties and 3 normal endometrial samples for the overexpression of both P-glycoprotein and GST-pi by means of immunohistochemistry. Both resistance markers were detectable in all tumor samples, and in normal endometrial tissue as well. The concomitant intrinsic overexpression of these two resistance mechanisms may in part explain why these tumors tend to be extremely resistant to chemotherapy.
子宫内膜癌被认为是一种对化疗反应不佳的肿瘤。在正在研究的各种化疗耐药机制中，其中两种（由P-糖蛋白介导的多药耐药和谷胱甘肽-S-转移酶-pi [GST-pi] 的过表达）引起了妇科肿瘤学家的极大兴趣，因为它们涉及几种临床常用药物，其中阿霉素和顺铂可能是最重要的两种。我们通过免疫组织化学研究了23例不同组织学类型的人子宫内膜癌和3例正常子宫内膜样本中P-糖蛋白和GST-pi的过表达情况。在所有肿瘤样本以及正常子宫内膜组织中均检测到了这两种耐药标志物。这两种耐药机制同时内在性过表达可能部分解释了为什么这些肿瘤往往对化疗具有极强的耐药性。
