Krause H F
Department of Otolaryngology, University of Pittsburgh School of Medicine, PA.
Otolaryngol Head Neck Surg. 1994 Sep;111(3 Pt 2):364-72. doi: 10.1177/01945998941113p205.
Therapy for patients with allergic rhinitis and urticaria has undergone considerable change in recent years because the mechanisms of these diseases have been more clearly elucidated. Both appear to have marked inflammatory components. A review of the recent literature reveals that clinical studies of both classic and new nonsedating H1-receptor antagonists, H2-receptor antagonists, a variety of intranasal medications, and mast-cell stabilizers demonstrate variable roles in the management of these diseases. Because allergic rhinitis has early- and late-phase reactions, therapy must be directed toward control of both responses. There are a number of types of urticaria; therapy for each may vary.
近年来，过敏性鼻炎和荨麻疹患者的治疗方法发生了很大变化，因为这些疾病的发病机制已得到更清晰的阐释。两者似乎都有明显的炎症成分。对近期文献的回顾显示，经典和新型非镇静性H1受体拮抗剂、H2受体拮抗剂、多种鼻内用药以及肥大细胞稳定剂的临床研究表明，它们在这些疾病的治疗中发挥着不同的作用。由于过敏性鼻炎有早期和晚期反应，治疗必须针对控制这两种反应。荨麻疹有多种类型，每种类型的治疗方法可能有所不同。
