Goldie J H
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada.
Lung Cancer. 1994 Mar;10 Suppl 1:S91-6. doi: 10.1016/0169-5002(94)91671-3.
Modelling the process of drug resistance can provide insight into such issues as the difference between intrinsic and acquired drug resistance. Other important biological questions such as whether resistance arises through selective or inducible events can also be addressed by reference to appropriate models. If drug resistant cells are produced by some type of inducible up regulation step then this has a number of qualifications for cancer chemotherapy. Selection theories of drug resistance imply that certain sequences of drugs will be superior to others something which can be tested by experiment.
对耐药性过程进行建模可以深入了解诸如固有耐药性和获得性耐药性之间的差异等问题。其他重要的生物学问题，例如耐药性是通过选择性事件还是诱导性事件产生的，也可以通过参考适当的模型来解决。如果耐药细胞是由某种类型的诱导性上调步骤产生的，那么这对癌症化疗有许多限制条件。耐药性的选择理论意味着某些药物序列将优于其他序列，这一点可以通过实验来检验。
