Ichikawa T, Ishihara K, Ogata Y, Ohara S, Saigenji K, Hotta K
Department of Biochemistry, Kitasato University School of Medicine, Kanagawa, Japan.
Jpn J Pharmacol. 1994 May;65(1):63-6. doi: 10.1254/jjp.65.63.
We examined the effects of Z-300 (N-[3-[3- (piperidinomethyl)phenoxy]propyl]-2-(2-hydroxy-ethyl-1-thio)acetam ido.2- (4-hydroxy benzoyl)benzoate), a newly-synthesized selective histamine H2-receptor antagonist, on mucin in rat gastric mucosa. Deep corpus mucin content increased significantly to 127% of the control after the administration of 30 mg/kg of Z-300, whereas that in the antral mucosa did not increase. The addition of Z-300 significantly increased [3H]-labeled mucin in the corpus region. In the antrum, biosynthetic activity showed no significant change by 10(-8)-10(-5) M of Z-300. These results suggest that Z-300 not only inhibits acid secretion but may also promote gastric mucus metabolism in the corpus region.
我们研究了新合成的选择性组胺H2受体拮抗剂Z - 300（N - [3 - [3 -（哌啶甲基）苯氧基]丙基]-2 -（2 - 羟乙基 - 1 - 硫代）乙酰胺.2 -（4 - 羟基苯甲酰基）苯甲酸酯）对大鼠胃黏膜黏蛋白的影响。给予30mg/kg的Z - 300后，胃体深层黏蛋白含量显著增加至对照的127%，而胃窦黏膜中的黏蛋白含量未增加。添加Z - 300显著增加了胃体区域[3H]标记的黏蛋白。在胃窦中，10(-8)-10(-5)M的Z - 300对生物合成活性无显著影响。这些结果表明，Z - 300不仅抑制胃酸分泌，还可能促进胃体区域的胃黏液代谢。
