McElroy J F
DuPont Merck Pharmaceutical Company, Wilmington, DE 19880-0400.
Pharmacol Biochem Behav. 1994 Jun;48(2):531-3. doi: 10.1016/0091-3057(94)90565-7.
7-Hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) is a high affinity and selective ligand at dopamine D3 receptors. Rats were trained to discriminate 7-OH-DPAT (0.05 mg/kg) from drug vehicle using a food-reinforced (FR 10) two-lever operant procedure. Six out of nine rats learned to discriminate 7-OH-DPAT, requiring a mean of 29 training sessions. After the training dose was increased to 0.10 mg/kg the remaining three rats reached discrimination performance criterion. The 7-OH-DPAT stimulus was dose-dependent. Doses of 0.01, 0.03, 0.056, and 0.1 mg/kg 7-OH-DPAT produced 0, 11, 78, and 100% drug-correct lever selection, respectively, with the ED50 value calculated to be 0.038 mg/kg. These results demonstrate that the D3-selective ligand 7-OH-DPAT can control differential operant responding in rats on the basis of its discriminative stimulus properties.
7-羟基-N,N-二正丙基-2-氨基四氢萘（7-OH-DPAT）是一种对多巴胺D3受体具有高亲和力和选择性的配体。使用食物强化（FR 10）双杠杆操作程序训练大鼠区分7-OH-DPAT（0.05毫克/千克）和药物载体。九只大鼠中有六只学会了区分7-OH-DPAT，平均需要29次训练。将训练剂量增加到0.10毫克/千克后，其余三只大鼠达到了区分性能标准。7-OH-DPAT刺激具有剂量依赖性。0.01、0.03、0.056和0.1毫克/千克的7-OH-DPAT剂量分别产生0、11、78和100%的药物正确杠杆选择，计算得出的ED50值为0.038毫克/千克。这些结果表明，D3选择性配体7-OH-DPAT可根据其辨别刺激特性控制大鼠的差异操作性反应。
