Izpisúa-Belmonte J C, De Robertis E M, Storey K G, Stern C D
Molecular Biology Institute, University of California, Los Angeles 90024-1737.
Cell. 1993 Aug 27;74(4):645-59. doi: 10.1016/0092-8674(93)90512-o.
The chick homeobox gene goosecoid (gsc) is first expressed in a barely noticeable cell population near the posterior margin (Koller's sickle) of the unincubated egg. Then it is detected in Hensen's node, traditionally considered the chick organizer. Later, gsc-expressing cells leave the node with the prechordal plate. Fate mapping indicates that these three regions are related by cell lineage, and transplantation experiments suggest that they all have inducing activity. Quail posterior margin and anterior primitive streak grafts (gsc expressing) induce gsc transcription in neighboring chick host cells. We propose that development of the chick organizer starts earlier than previously thought and that gsc marks this changing cell population.
鸡的同源盒基因鹅膏蕈氨酸（gsc）最初在未孵化卵后缘（科勒镰刀带）附近一个几乎难以察觉的细胞群体中表达。然后在传统上被认为是鸡胚组织者的亨森结中被检测到。后来，表达gsc的细胞与脊索前板一起离开结节。命运图谱表明这三个区域通过细胞谱系相关联，移植实验表明它们都具有诱导活性。鹌鹑后缘和前原条移植物（表达gsc）在相邻的鸡宿主细胞中诱导gsc转录。我们提出鸡胚组织者的发育比以前认为的开始得更早，并且gsc标记了这个不断变化的细胞群体。
