Georgatos S D, Meier J, Simos G
European Molecular Biology Laboratory, Heidelberg, Germany.
Curr Opin Cell Biol. 1994 Jun;6(3):347-53. doi: 10.1016/0955-0674(94)90025-6.
A variety of morphological and biochemical studies have established that the nuclear lamins play an important role in nuclear structure and dynamics. Recent work reveals the existence of specialized lamin isotypes and novel pathways of modulation of lamin import into the nucleus via phosphorylation by protein kinase C. Other studies also unveil a wide spectrum of molecular interactions between the lamin proteins and integral membrane components of the nuclear envelope.
多种形态学和生物化学研究已证实,核纤层蛋白在细胞核结构和动态变化中发挥着重要作用。近期研究发现了特殊的核纤层蛋白同种型以及通过蛋白激酶C磷酸化调节核纤层蛋白导入细胞核的新途径。其他研究还揭示了核纤层蛋白与核膜整合膜成分之间广泛的分子相互作用。