Carlson M, Laurent B C
Department of Genetics and Development, Columbia University, New York, NY 10032.
Curr Opin Cell Biol. 1994 Jun;6(3):396-402. doi: 10.1016/0955-0674(94)90032-9.
The yeast SNF/SWI proteins have a global role in transcriptional activation. This set of five proteins assists many gene-specific activators, most likely by altering chromatin structure to relieve repression. Recent work shows that the SNF/SWI proteins function together in a multiprotein complex and that SNF2 has DNA-dependent ATPase activity. SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation.
酵母SNF/SWI蛋白在转录激活中发挥全局作用。这一组五种蛋白协助许多基因特异性激活因子，很可能是通过改变染色质结构来解除抑制作用。最近的研究表明，SNF/SWI蛋白在一个多蛋白复合物中共同发挥作用，并且SNF2具有依赖于DNA的ATP酶活性。现在已经在果蝇、小鼠和人类中鉴定出SNF/SWI同源物，这表明它们在转录激活中具有保守作用。
