Falaschi P, Martocchia A, Proietti A, Pastore R, D'Urso R, Barnaba V
Dipartimento di Internistica Clinica e Sperimentale, II Università degli Studi di Napoli.
Ann Ital Med Int. 1994 Apr-Jun;9(2):96-9.
Interest in neuroendocrinoimmunology has increased greatly in the last decade. The most important evidence of neuroendocrine-immune system interactions is that spleen, thymus, bone marrow and lymph nodes are innervated by neurons of the autonomic nervous system; changes in brain functions can affect different immune responses; immune and neuroendocrine cells share receptors (e.g., lymphocytes and macrophages have receptors for a vast number of hormones and neuropeptides); hormones and neuropeptides can alter the functional activity of immune system cells; several hormones and neuropeptides can be synthesized by leukocytes; cytokines produced by leukocytes are able to modulate neuroendocrine system activity, behaviour, sleep and thermoregulation. The recent literature on neuroendocrinoimmunology has laid the physiopathological groundwork for a new clinical approach which perceives and treats the patient as a psychic and somatic whole.
在过去十年中，人们对神经内分泌免疫学的兴趣大幅增加。神经内分泌系统与免疫系统相互作用的最重要证据包括：脾脏、胸腺、骨髓和淋巴结受自主神经系统神经元支配；脑功能的变化可影响不同的免疫反应；免疫细胞和神经内分泌细胞共享受体（例如，淋巴细胞和巨噬细胞具有大量激素和神经肽的受体）；激素和神经肽可改变免疫系统细胞的功能活性；几种激素和神经肽可由白细胞合成；白细胞产生的细胞因子能够调节神经内分泌系统的活动、行为、睡眠和体温调节。最近关于神经内分泌免疫学的文献为一种新的临床方法奠定了生理病理学基础，这种方法将患者视为一个精神和躯体的整体来认识和治疗。
