Narayanan M N, Morgenstern G R, Chang J C, Harrison C J, Ranson M, Scarffe J H
Department of Haematology, Christie Hospital, Manchester.
Br J Haematol. 1994 Apr;86(4):867-9. doi: 10.1111/j.1365-2141.1994.tb04844.x.
Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
霍奇金淋巴瘤（HD）患者发生的急性白血病，无论是髓系还是淋巴细胞系，预后都被认为较差。我们报告了4例成年患者，他们在接受HD放化疗后发生了继发性急性淋巴细胞白血病（ALL）。在两名接受含有DNA拓扑异构酶II抑制剂依托泊苷化疗方案的患者中发现了染色体易位t(4;11)(q21;q23)。4例患者中有3例存活，自ALL诊断起3年、5年和9年处于未维持的首次缓解期，其中2例在自体骨髓移植后缓解。这些结果表明，HD后继发的ALL积极治疗后可能预后良好。
