de Celis J F, García-Bellido A
Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain.
Mech Dev. 1994 May;46(2):109-22. doi: 10.1016/0925-4773(94)90080-9.
The Notch gene encodes a transmembrane protein that functions as a receptor of intercellular signals in many developmental processes of Drosophila. We study here the Notch function in wing morphogenesis and vein patterning in genetic mosaics of both Notch null and Notch gain-of-function alleles. Cell proliferation and differentiation properties of mutant Notch cells define three different Notch requirements in the wing: in imaginal disc cell proliferation, in restriction of vein differentiation and in margin formation. The study of Notch mosaics in different mutant backgrounds reveals that Notch activity during epidermal cell proliferation and wing vein differentiation is exerted by its regulation of a common group of genes involved in the specification and restriction of vein competent regions.
Notch基因编码一种跨膜蛋白，在果蝇的许多发育过程中作为细胞间信号的受体发挥作用。我们在此研究Notch基因在Notch基因缺失和功能获得性等位基因的遗传嵌合体中的翅膀形态发生和翅脉模式形成中的功能。突变型Notch细胞的细胞增殖和分化特性确定了翅膀中Notch的三种不同需求：在成虫盘细胞增殖中、在翅脉分化的限制中以及在边缘形成中。在不同突变背景下对Notch嵌合体的研究表明，表皮细胞增殖和翅脉分化过程中的Notch活性是通过其对一组参与翅脉感受态区域的特化和限制的共同基因的调控来发挥作用的。
