Tufveson G, Bäckman L, Berglin E, Blohmé I, Breimer M, Friman S, Holmberg S, Lindnér P, Mjörnstedt L, Nordén G
Division of Transplantation and Liver Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
Clin Transpl. 1993:243-51.
The limiting factor in organ transplantation is the availability of organs. Continuing work to improve the public's willingness to donate organs and inspire hospital staff to collaborate in organ procurement is essential. Identification of patients who will not benefit from transplantation can also increase the availability of organs. Grafts may also be saved by identification and appropriate treatment of recurrent renal disease. Xenotransplantation may eventually solve the problem, but major obstacles remain. Meanwhile, work in this field may help to clarify mechanisms of rejection. New immunosuppressive drugs may improve graft survival and reduce the incidence and progression of chronic rejection.
器官移植的限制因素是器官的可获得性。持续努力提高公众器官捐赠意愿并激励医院工作人员在器官获取方面进行协作至关重要。识别那些无法从移植中获益的患者也可增加器官的可获得性。通过识别和适当治疗复发性肾病也可挽救移植器官。异种移植最终可能解决这一问题，但主要障碍依然存在。与此同时，该领域的研究可能有助于阐明排斥反应的机制。新型免疫抑制药物可能改善移植器官的存活情况并降低慢性排斥反应的发生率和进展。
