Sallingová Z, Kohút A
Department of Pharmacology, Faculty of Medicine, Safarik University, Slovak Republic.
Physiol Res. 1994;43(2):95-9.
Pentoxifylline pretreatment protects rat gastric mucosa against indomethacin-induced damage. Lipid peroxidation after indomethacin treatment (determined as thiobarbituric acid reactants) was significantly reduced by a single dose of pentoxifylline. The same was true for pentoxifylline administration for 6 days. There is a relationship between reduced lipid peroxidation, decreased number of circulating activated neutrophils and diminished disposition for acute gastric mucosal lesions induced by indomethacin in pentoxifylline-pretreated rats.
己酮可可碱预处理可保护大鼠胃黏膜免受吲哚美辛诱导的损伤。吲哚美辛治疗后的脂质过氧化（以硫代巴比妥酸反应物测定）通过单剂量己酮可可碱显著降低。连续6天给予己酮可可碱也是如此。在己酮可可碱预处理的大鼠中，脂质过氧化降低、循环活化中性粒细胞数量减少与吲哚美辛诱导的急性胃黏膜损伤倾向减轻之间存在关联。
