通过碘美西尼单光子发射计算机断层扫描测量惊恐障碍中苯二氮䓬受体结合减少。初步报告。
Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary report.
作者信息
Schlegel S, Steinert H, Bockisch A, Hahn K, Schloesser R, Benkert O
机构信息
Department of Psychiatry, University of Mainz, Germany.
出版信息
Eur Arch Psychiatry Clin Neurosci. 1994;244(1):49-51. doi: 10.1007/BF02279812.
Single photon emission tomography (SPECT) imaging of the central benzodiazepine receptor (BZr) became possible with the newly developed ligand 123I-IOMAZENIL. The BZr binding was investigated in ten patients with panic disorder (PP) compared to ten epileptic patients (EP). Panic patients had lower IOMAZENIL uptake rates in the frontal, occipital and temporal cortex than EP indicating the involvement of the BZr complex in panic disorder.
新型配体123I-碘马西尼使得对中枢苯二氮䓬受体（BZr）进行单光子发射断层扫描（SPECT）成像成为可能。与10名癫痫患者（EP）相比，对10名惊恐障碍患者（PP）的BZr结合情况进行了研究。惊恐障碍患者额叶、枕叶和颞叶皮质的碘马西尼摄取率低于癫痫患者，这表明BZr复合物与惊恐障碍有关。
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