Raghavan K, Dwivedi A, Campbell G C, Nemeth G, Hussain M A
DuPont Merck Pharmaceutical Co., Wilmington, DE 19880-0400.
J Pharm Biomed Anal. 1994 Jun;12(6):777-85. doi: 10.1016/0731-7085(94)e0002-i.
DuP 747, a selective kappa agonist analgesic, was found to have at least two polymorphic forms, and this was confirmed by X-ray powder diffraction. DSC and thermomicroscopic studies indicated the polymorphic pair to be monotropic. Solubility studies suggested the relative stability of the two forms to be similar. The infrared (IR) and Raman spectra of the two crystal forms were significantly different, and their complementary nature was shown from the differences in peak intensities. Solid-state 13C-NMR data of the polymorphs showed only minor differences between the two forms. When viewed on the molecular level through the use of vibrational and NMR spectroscopies, the conformation of the molecule in the two polymorphs appears to be roughly equivalent. The magnitude of the spectral differences of the two polymorphs is, however, consistent with those that can be expected for two crystal forms that have resulted from different modes of packing, as caused by the solvent environment.
杜匹鲁胺747是一种选择性κ激动剂镇痛药，被发现至少有两种多晶型物，这通过X射线粉末衍射得到了证实。差示扫描量热法（DSC）和热显微镜研究表明，这两种多晶型物呈单向性。溶解度研究表明，这两种晶型的相对稳定性相似。两种晶型的红外（IR）光谱和拉曼光谱有显著差异，并且从峰强度的差异显示出它们的互补性质。多晶型物的固态13C - NMR数据表明，两种晶型之间只有微小差异。当通过振动光谱和NMR光谱在分子水平上观察时，两种多晶型物中分子的构象似乎大致相同。然而，两种多晶型物光谱差异的大小与由溶剂环境导致的不同堆积模式所产生的两种晶型所预期的差异一致。
