McIntosh M A, Hicks M N, Kane K A, Rankin A C, Cobbe S M
Department of Medical Cardiology, Royal Infirmary, Glasgow.
Cardioscience. 1994 Jun;5(2):95-100.
A rabbit model of left ventricular hypertrophy is characterized with respect to blood pressure, heart mass and ventricular refractoriness. Hypertension and left ventricular hypertrophy was induced by unilateral nephrectomy plus wrapping of the contralateral kidney in cellophane. Control or sham operated animals were subjected to a similar procedure except that the kidney was not wrapped in cellophane. No change in conscious mean arterial blood pressure was shown in the 11 sham operated animals (75 +/- 2 mmHg before operation and 75 +/- 3 mmHg 4-5 weeks after). Mean arterial pressure was increased from 73 +/- 2 to 99 +/- 3 mmHg by 4-5 weeks and had reached a plateau of 110 +/- 3 mmHg 5-6 weeks after operation in the 16 animals in which the kidney was wrapped. The ratios of left ventricular dry weight to body weight and of whole heart wet weight to body weight were significantly (p < 0.05) higher in the wrap group (0.38 +/- 0.01 and 2.97 +/- 0.12, respectively) than in the sham group (0.29 +/- 0.01 and 2.44 +/- 0.08 respectively). Effective refractory period, recorded from the left side of the arterially perfused interventricular septum, was greater in the wrap (266.1 +/- 8.9 ms) than in the sham group (228.2 +/- 3.5 ms). Linear correlations were shown between mean arterial pressure or effective refractory period vs the ratio of left ventricular dry weight to body weight or ratio of whole heart to body weight. This study has shown that hypertension induced by perinephritis caused left ventricular hypertrophy which was associated with a prolongation in ventricular refractoriness in the rabbit.
对左心室肥厚兔模型的血压、心脏质量和心室不应期进行了表征。通过单侧肾切除术加用玻璃纸包裹对侧肾脏诱导高血压和左心室肥厚。对照或假手术动物接受类似的手术，只是肾脏未用玻璃纸包裹。11只假手术动物的清醒平均动脉血压无变化（术前75±2 mmHg，术后4 - 5周75±3 mmHg）。在16只肾脏被包裹的动物中，平均动脉压在术后4 - 5周从73±2 mmHg升高到99±3 mmHg，并在术后5 - 6周达到110±3 mmHg的平台期。包裹组的左心室干重与体重之比以及全心湿重与体重之比（分别为0.38±0.01和2.97±0.12）显著高于假手术组（分别为0.29±0.01和2.44±0.08）（p<0.05）。从动脉灌注的室间隔左侧记录的有效不应期，包裹组（266.1±8.9 ms）长于假手术组（228.2±3.5 ms）。平均动脉压或有效不应期与左心室干重与体重之比或全心与体重之比之间呈线性相关。本研究表明，肾炎引起的高血压导致兔左心室肥厚，且与心室不应期延长有关。
