St John W M, Wang S C
J Appl Physiol. 1976 Nov;41(5 Pt. 1):612-22. doi: 10.1152/jappl.1976.41.5.612.
Ventilatory regulation by pontile pneumotaxic and apneustic centers and by rostral medullary sites was evaluated in intercollicular decerebrate cats. Following pneumotaxic center ablation, PAco2 was significantly elevated. Moreover, in response to hypercapina or hypoxia, frequency responses were significantly diminished whereas tidal volume responses were unchanged or elevated. Interruption of apneustic center function by caudal pontile transection or radiofrequency lesions in the caudal pons and/or rostral medulla resulted in significant decreases of tidal volume responses and significant elevations of frequency responses to both hypercapnia and hypoxia. Neither minute volume responses nor the PAco2 level was altered. It is concluded that the apneustic center exercises a primary role in the brainstem definition of tidal volume responses for both peripheral and central chemoreceptor afferent stimuli. The apneustic center is also considered to exert an impoetant function in the definition of respiratory frequency. A medially placed pathway in the rostral medulla is proposed to interconnect the apneustic center with the medullary respiratory nuclei.
在间脑桥脑离大脑猫中评估脑桥呼吸调整中枢和长吸中枢以及延髓头端部位对通气的调节作用。在呼吸调整中枢切除后，动脉血二氧化碳分压（PACO₂）显著升高。此外，对高碳酸血症或低氧的反应中，频率反应显著减弱，而潮气量反应未改变或升高。通过脑桥尾端横断或在脑桥尾端和/或延髓头端进行射频损伤来中断长吸中枢功能，导致对高碳酸血症和低氧的潮气量反应显著降低，频率反应显著升高。分钟通气量反应和PACO₂水平均未改变。得出的结论是，长吸中枢在脑干确定外周和中枢化学感受器传入刺激的潮气量反应中起主要作用。长吸中枢也被认为在呼吸频率的确定中发挥重要作用。提出延髓头端一条位于内侧的通路将长吸中枢与延髓呼吸核相连。
