Schlaefke M E, Kille J F, Loeschcke H H
Pflugers Arch. 1979 Jan 31;378(3):231-41. doi: 10.1007/BF00592741.
Breathing and respiratory response to CO2 were observed in 6 awake cats and 1 control before and after bilateral coagulation of the formerly described area S (Schläfke and Loeschcke, 1967) on the ventral medullary surface under hyperoxic conditions. Ventilation decreased, PCO2 rose and CO2 response was almost or completely abolished in 4 cats, and moderately reduced in 2 cats. Inhalation of CO2 had an inhibitory effect on ventilation in two cases. In some instances the respiratory frequency was increased by CO2. Periodic breathing as well as spontaneous hyperventilation elicited by 'arousal' indicate parallels to the Pickwickian or Ondine's curse syndrome. No respiratory changes were produced by a lesion on the pyramidal tract medial to the area S. It is concluded that central chemosensitivity can be eliminated within the superficial layer of the area S. The loss of CO2 response seems to be correlated with complete destruction of the superficial nerve cells located within the area S (Petrovický, 1968) and degeneration within the ventral part of the nucleus paragigantocellularis.
在高氧条件下，对6只清醒猫和1只对照猫在双侧凝固延髓腹侧表面先前描述的区域S（施莱夫克和勒施克，1967年）之前和之后的呼吸及对二氧化碳的呼吸反应进行了观察。4只猫的通气量下降，二氧化碳分压升高，对二氧化碳的反应几乎或完全消失，2只猫的反应适度降低。在两例中，吸入二氧化碳对通气有抑制作用。在某些情况下，二氧化碳会增加呼吸频率。周期性呼吸以及由“觉醒”引发的自发性过度通气表明与匹克威克综合征或翁丁氏诅咒综合征有相似之处。在区域S内侧的锥体束上的损伤未产生呼吸变化。得出的结论是，区域S表层内的中枢化学敏感性可以被消除。对二氧化碳反应的丧失似乎与区域S内表层神经细胞的完全破坏（彼得罗维茨基，1968年）以及巨细胞旁核腹侧部分的变性有关。
