Wiegand H, Heck M, Gotzsch U
Medical Institute of Environmental Hygiene, Heinrich-Heine-University Düsseldorf, Department of Neurotoxicology, Germany.
Neuroreport. 1994 Jun 27;5(11):1369-72.
The inhibition by lead of motor terminal calcium plateau signals has been studied using extracellular, perineuronal electrodes applied to the M. triangularis sterni preparation of the mouse. The long-lasting calcium pateau signal induced by 3,4-DAP (250 mumol) and TEA (10 mmol) blockade of presynaptic potassium channels was irreversibly blocked by micromolar lead concentrations in a concentration-dependent manner. These results suggest that lead antagonizes neuronal calcium channels involved in transmitter release from motor nerve terminals.
