环丙亚胺类：新型生物还原抗癌剂——作用机制与酶促还原
Cyclopropamitosenes: novel bioreductive anticancer agents--mechanism of action and enzymic reduction.
作者信息
Moody C J, O'Sullivan N, Stratford I J, Stephens M A, Workman P, Bailey S M, Lewis A
机构信息
Department of Chemistry, Loughborough University of Technology, UK.
出版信息
Anticancer Drugs. 1994 Jun;5(3):367-72.
PMID:7919462
Abstract
The mechanism of action of cyclopropamitosenes, novel bioreductive anticancer agents, has been investigated using a unique combination of chemical and biochemical techniques. The compounds 4 function as reductively activated alkylating agents under chemical reducing conditions, and the biochemical experiments establish that the methoxy- and aziridinyl-derivatives 4a and 4b behave differently upon bioreduction.
摘要
环丙亚胺醌类新型生物还原抗癌剂的作用机制已通过化学和生化技术的独特组合进行了研究。化合物4在化学还原条件下作为还原活化的烷基化剂起作用，生化实验表明，甲氧基和氮丙啶基衍生物4a和4b在生物还原时表现不同。
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